This paper presents EdgeSAM, an accelerated variant of the Segment Anything Model (SAM), optimized for efficient execution on edge devices with minimal compromise in performance. Our approach involves distilling the original ViT-based SAM image encoder into a purely CNN-based architecture, better suited for edge devices. We carefully benchmark various distillation strategies and demonstrate that task-agnostic encoder distillation fails to capture the full knowledge embodied in SAM. To overcome this bottleneck, we include both the prompt encoder and mask decoder in the distillation process, with box and point prompts in the loop, so that the distilled model can accurately capture the intricate dynamics between user input and mask generation. To mitigate dataset bias issues stemming from point prompt distillation, we incorporate a lightweight module within the encoder. As a result, EdgeSAM achieves a 37-fold speed increase compared to the original SAM, and it also outperforms MobileSAM/EfficientSAM, being over 7 times as fast when deployed on edge devices while enhancing the mIoUs on COCO and LVIS by 2.3/1.5 and 3.1/1.6, respectively. It is also the first SAM variant that can run at over 30 FPS on an iPhone 14. Code and demo are available at https://www.mmlab-ntu.com/project/edgesam.