We firstly simulated disease dynamics by KAN (Kolmogorov-Arnold Networks) nearly 4 years ago, but the kernel functions in the edge include the exponential number of infected and discharged people and is also in line with the Kolmogorov-Arnold representation theorem, and the shared weights in the edge are the infection rate and cure rate, and used activation function by tanh at the node of edge. And this Arxiv preprint version 1 of March 2022 is an upgraded version of KAN, considering the invariant coarse-grained which calculated by residual or gradient of MSE loss. The improved KAN is PNN (Plasticity Neural Networks) or ELKAN (Edge Learning KNN), in addition to edge learning, it also considered the trimming of the edge. We not inspired by the Kolmogorov-Arnold representation theorem but inspired by the brain science. The ELKAN to explain brain, the variables correspond to different types of neurons, the learning edge can be explained by rebalance of synaptic strength and glial cells phagocytose synapses, and the kernel function means the discharge of neurons and synapses, different neurons and edges mean brain regions. Through testing by cosine, the ELKAN or ORPNN (Optimized Range PNN) is better than the KAN or CRPNN (Constant Range PNN).The ELKAN is more general to explore brain, such as mechanism of consciousness, interactions of natural frequencies in brain regions, synaptic and neuronal discharge frequencies, and data signal frequencies; mechanism of Alzheimer's disease, the Alzheimer's patients has more high frequencies in the upstream brain regions; long short-term relatively good and inferior memory which means gradient of architecture and architecture; turbulent energy flow in different brain regions, turbulence critical conditions need to be met; heart-brain of the quantum entanglement may occur between the emotions of heartbeat and the synaptic strength of brain potentials.